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. 2012 Mar 5;2(3):283–294. doi: 10.7150/thno.3642

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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A. Scheme showing sequential delivery of siRNA and anticancer drugs by PEI-GO. B. Relative viability of HeLa cells treated with (1) PEI-GO/Bcl-2 targeted siRNA, and (2) PEI-GO/scrambled siRNA, followed by incubation with PEI-GO/DOX. C. IC₅₀ of DOX for the HeLa cells sequentially incubated with (1) PEI-GO/Bcl-2 targeted siRNA and PEI-GO/DOX, and (2) PEI-GO/scrambled siRNA and PEI-GO/DOX. The result indicates that PEI-GO/Bcl-2-targeted siRNA complexes significantly enhanced the cytotoxicity of the PEI-GO/DOX. ⁵⁴ Copyright Wiley-VCH Verlag GmbH & Co. KGaA. Reproduced with permission.