Table 1.
Characteristics of CLL rAbs used in present investigation
| Recombinant IgG | IGHV gene | IGHD gene | IGHJ gene | % germ line identity | HCDR3 sequence | IGKV/IGLV gene | % germ line identity | LCDR3 sequence |
|---|---|---|---|---|---|---|---|---|
| CLL69A | IGHV1-69 | D3-16 | JH3 | 100 | GGIYDYVWGSYRPNDAFDI | IGKV3-20 | 100 | QQYGSSPGT |
| CLL69B | IGHV1-69 | D2-02 | JH6 | 100 | MRPDIVVVPAAISYYYGMDV | IGKV1-39 | 100 | QQSYSTPRT |
| CLL69D | IGHV1-69 | D2-02 | JH6 | 100 | GGDIVVVPAAMSYYYYGMDV | IGKV3-11 | 100 | QQRSNT |
| CLL3-21U1 | IGHV3-21 | JH6 | 99 | DQNGMDV | IGLV3-21 | 99.3 | QVWDAGSDHPWV | |
| CLL3-21U2 | IGHV3-21 | D6-13 | JH4 | 100 | DPSFYSSSWTLFDY | IGKV3-20 | 100 | QQYGSSPLT |
| CLL3-21M1 | IGHV3-21 | JH6 | 95.4 | DGNGMDV | IGLV3-21 | 97 | QVWDSGSDHPWV | |
| CLL4-39A | IGHV4-39 | D2-02 | JH6 | 100 | HRLGYCSSTSCYYYYYGMDV | IGLV1-40 | 99.7 | QSYDSSLSVV |
| GW21 | IGHV1-69 | D5-24 | JH4 | 99.7 | DGEMATDDHFDY | IGLV1-40 | 99.7 | QSYDSSLSVV |
| MU08 | IGHV1-69 | D3-10 | JH5 | 100 | AGYGSGTYWFDP | IGLV1-40 | 99.7 | QSYDSSLSVV |