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CYP2E1KO mice have improved glucose tolerance compared with WT mice on HFD. Four-week-old WT and CYP2E1KO male mice were fed for 8 wk (A) or 12 wk (B) with NCD or HFD. After a 5-h overnight fast, mice were given an injection (1 g/kg ip) of d-glucose in saline. Blood glucose levels were measured by glucometer after 0, 15, 30, 60, and 120 min. Results represent means ± SE of data from 4–6 mice per group. *P < 0.05, WT-HFD vs. other 3 group; **P < 0.05, CYP2E1KO-HFD vs. both NCD groups.
