Table 1.

Weight and plasma clinical chemistry in WT and apoE^−/− mice fed a standard or high-fat diet

	2 wk	4 wk	8 wk
Weight (change from baseline), g
WT/standard diet	2.1 ± 0.6	3.6 ± 0.2	5.0 ± 0.5
WT/high-fat diet	3.5 ± 0.9	10.3 ± 0.2*	11.0 ± 1.5*
apoE−/−/standard diet	3.7 ± 0.1	4.3 ± 0.2	4.2 ± 0.2
apoE−/−/high-fat diet	3.5 ± 0.3	4.7 ± 0.2	10.0 ± 0.9*
Total cholesterol, mg/dl
WT/standard diet	<45†	86 ± 2	81 ± 8
WT/high-fat diet	104 ± 16	248 ± 14*	194 ± 23*
apoE−/−/standard diet	614 ± 84*	512 ± 49*	918 ± 70*
apoE−/−/high-fat diet	902 ± 207*	1,099 ± 130*	1,398 ± 125*
Insulin, ng/ml
WT/standard diet	0.72 ± 0.08	0.95 ± 0.14	0.68 ± 0.14
WT/high-fat diet	2.23 ± 0.61*	2.67 ± 0.54*	4.55 ± 0.82*
apoE−/−/standard diet	0.83 ± 0.08	0.56 ± 0.04	1.06 ± 0.17
apoE−/−/high-fat diet	1.90 ± 0.54*	1.72 ± 0.31*	4.09 ± 0.87*
Glucose, mg/dl
WT/standard diet	331 ± 19	399 ± 52	335 ± 15
WT/high-fat diet	446 ± 57	386 ± 26	382 ± 32
apoE−/−/standard diet	359 ± 16	325 ± 19	306 ± 20
apoE−/−/high-fat diet	361 ± 34	382 ± 19	418 ± 34

Values are means ± SE.

WT, wild-type; apoE, apolipoprotein E.

^*P < 0.05 compared with WT/standard diet.

^†All values were below the limit of quantitation.