Fig. 1.
Effect of prenatal programming on basal cortical collecting duct osmotic water permeability (Pf) and the Pf in response to vasopressin. Adult rat cortical collecting ducts were perfused in vitro for at least 30 min before Pf was measured, which was not different from zero in male rats born from mothers who ate a 20% control diet or a 6% low-protein diet during the last half of gestation. Addition of 10−10 M vasopressin resulted in an increase in Pf that was not different between the low-protein and control group. The increase in Pf was significant in both groups (*P < 0.001).