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ANG II activated renal dopamine-metabolizing system and decreased renal dopamine levels. A: chronic ANG II infusion led to increases in expression of MAO and COMT. B: at baseline, renal dopamine levels were higher in COMT KO mice than in wild-type. ANG II infusion decreased renal dopamine levels in wild-type but not COMT KO mice (*P < 0.05 vs. control wild-type, n = 4 in each group).
