Table 2.
List of candidate genes
| Gene Title | Pubmetrix |
|||
|---|---|---|---|---|
| Gene Symbol | Kidney IRI | Renal inflammation | Immune cell trafficking | |
| Genes associated with chemokines | ||||
| C-C motif chemokine ligand 7 | CCL7 | 0 | 4 | 14 |
| C-C motif chemokine receptor 5 | CCR5 | 1 | 26 | 165 |
| C-C motif chemokine receptor 2 | CCR2 | 3 | 28 | 91 |
| C-C motif chemokine ligand 5 | CCL5 | 7 | 62 | 115 |
| C-C motif chemokine receptor 3 | CCR3 | 0 | 4 | 49 |
| Genes related to cytokine signaling | ||||
| Tumor necrosis factor-α | TNF-α | 169 | 965 | 253 |
| Suppressor of cytokine signaling 3 | SOCS3 | 3 | 6 | 1 |
| Toll-like receptor 4 | TLR4 | 7 | 51 | 30 |
| Protein tyrosine phosphatase Rc | PTPRC | 4 | 10 | 58 |
| IL-15 | IL-15 | 1 | 8 | 8 |
| Costimulatory molecules | ||||
| CD80 | CD80 | 11 | 11 | 36 |
| CD86 | CD86 | 6 | 8 | 46 |
| CD40 | CD40 | 1 | 29 | 55 |
| Transcript factor CP2 | Tfcp2 | 0 | 0 | 1 |
| MAPK9 | MAPK9 | 3 | 6 | 2 |
Genes which showed significant changes (fold-change >2.0 or <−2.0 and P < 0.05) at more than 3 time points studied) were listed as candidate genes. Pubmetrix analysis demonstrated that 12, 14, and 15 genes among 15 candidate genes were related to kidney IRI, renal inflammation, and immune cell trafficking, respectively, in the current PubMed database. (Genes in italics were downregulated.)