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Expression of SZP in (A) regions of high in vivo loading (M1) in the femoral condyles of bovine stifle joints is (B) significantly greater than in regions experiencing lower contact stresses (M4). L, lateral condyle; M, medial condyle; 1–4, locations on condyle numbered from anterior to posterior. SZP expression is (C) increased by sliding shear loading in cartilage explants obtained from M1. SZP synthesis in M4 explants is unaffected by shear. (Mean±SEM, *p=0.021).
