Fig. 2.
Rosiglitazone attenuated ethanol-induced adipose mass reduction, histopathological alterations, and inflammation. Mice were fed ethanol liquid diet for 8 wk, and rosiglitazone was supplemented in the liquid diet at 10 mg·kg body wt−1·day−1 for the last 3 wk. A: white adipose tissue (WAT) weight. sWAT, subcutaneous WAT. B: WAT histopathology. Hematoxylin and eosin staining. Arrows indicate inflammatory cell infiltration. C: adipocyte diameter. D: qRT-PCR analysis of inflammatory markers in WAT. Data are expressed as means ± SD; n = 6–8 in A; n = 200–240 in C; n = 4 in D. Means without a common letter differ at P < 0.05. In C, means of epididymal adipocyte diameter differ at P < 0.001. In D, means of IL-6 differ at P < 0.001; means of TNF-α and MCP-1 differ at P < 0.01.