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. 2011 Dec 23;302(5):H1146–H1159. doi: 10.1152/ajpheart.00668.2011

Table 1.

Ionic currents investigated in this study, drugs targeting them, and modulation of atrial electrophysiological properties

Ionic Current and Drug References Important Effects
INaK
    Amiodarone 26, 30 APD90, Ss1s2, Sdyn, RP, DF
    Strophantidin 40
    Digitalis 43
    Digoxin 55
    Ouabain 72
IK1
    Adenosine 3 APD90, RMP, Ss1s2, Sdyn, RP, CV, DF
INa
    Ranolazine 8 RP (AFER), CV, DF
    Flecainide 8
    Propafenone 8
    Lidocaine 15
    Pilsicainide 33
    Tetrodotoxin 39
IKur, Ito
    AVE118 5 APD90, RP, Ss1, s2, Sdyn
ICaL
    Verapamil 64 APD90, RP, Ss1s2
IKr, IKs
    Sotalol 19 -
    Dofetilide 19

INaK, Na+/K+ pump current; IK1, inward rectifier potassium current; INa, Na+ current; IKur, ultrarapid delayed potassium current; Ito, transient outward current; ICaL, L-type calcium current; IKr, rapid delayed rectifier potassium current; IKs, slow delayed rectifier potassium current; APD90, action potential duration at 90% repolarization; Ss1s2 and Sdyn, maximal values of the slopes of the S1S2 and dynamic action potential duration at 90% repolarization; RP, refractory period; RMP, resting membrane potential; CV, conduction velocity; DF, dominant frequency; AFER, atrial fibrillation-related electrical remodeling.