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. Author manuscript; available in PMC: 2012 Mar 23.
Published in final edited form as: Neuropharmacology. 2009 Nov 24;58(3):650–659. doi: 10.1016/j.neuropharm.2009.11.008

Figure 4.

Figure 4

Activation of SK channels with EBIO (17.5 mg/kg), or blockade of SK channels with apamin (0.4 mg/kg) did not affect the encoding of contextual or cued fear memory during conditioning with a 3 CS-US pairing protocol. Mice that received EBIO (n = 23) or vehicle (n = 23) before conditioning exhibited equivalent freezing during (A) the context test 24 h later, and during (B) the tone test. Mice that received apamin (0.4 mg/kg, n = 10) or saline (n = 10) before conditioning with 3 CS-US pairs also exhibited equivalent freezing during (C) the context test 24 h later, and during (D) the tone test. Error bars are SEM.