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. 2012 Jan 11;302(5):R620–R626. doi: 10.1152/ajpregu.00617.2011

Fig. 1.

Fig. 1.

Reduced uterine perfusion pressure (RUPP) and cobalt protoporphyrin (CoPP) treatment affect placental phosphorylation of MAPKs in rats. Pregnant rats were subjected to RUPP then treated with CoPP or vehicle, as described in materials and methods. A group of normal pregnant (NP) rats were also treated with either CoPP or vehicle. On gestational day 19, placentas were excised and processed to obtain protein lysates. All groups included three placentas from different animals. A: phosphorylation of ERK was determined by Western blot analysis and compared with the unphosphorylated ERK. NP, normal pregnant; RUPP, reduced uterine perfusion pressure; CoPP, cobalt protoporphyrin. B: densitometry of data in A. Ratio of pERK2/ERK2 was calculated. aP < 0.05 compared with RUPP. C: phosphorylation of JNK was determined by Western blot analysis and compared with the unphosphorylated JNK. NP, normal pregnant; RUPP, reduced uterine perfusion pressure; CoPP, cobalt protoporhyrin. D: densitometry of data in C. Ratio of pJNK/JNK was calculated. aP < 0.05 compared with NP. bP < 0.05 compared with RUPP.