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A: heart rate (HR) responses to chronic ICV infusion of MC3/4R antagonist SHU-9119 (1 nmol/h) on HR. B: changes in HR during chronic MC3/4R infusion in lean (n = 6) and obese (n = 8) Zucker rats. C: area under the curve of HR during SHU-9119 infusion. Data are presented as means ± SE. *P < 0.05 vs. control period (1-way ANOVA repeated measures). Comparisons between groups were made using 2-way ANOVA with repeated measures.
