Table 1.
Spontaneous BRS measured by the sequence method in lean and obese Zucker rats
| Groups | Seq Up, ms/mmHg | Seq Down, ms/mmHg | Seq All, ms/mmHg |
|---|---|---|---|
| Lean Zucker (n = 6) | |||
| Control | 1.24 ± 0.13 | 1.19 ± 0.14 | 1.27 ± 0.13 |
| SHU-9119 | 1.12 ± 0.07 | 1.17 ± 0.22 | 1.17 ± 0.15 |
| Recovery | 1.14 ± 0.19 | 1.29 ± 0.22 | 1.22 ± 0.20 |
| Obese Zucker (n = 8) | |||
| Control | 1.34 ± 0.20 | 1.32 ± 0.30 | 1.33 ± 0.20 |
| SHU-9119 | 1.96 ± 0.51 | 1.63 ± 0.41 | 1.77 ± 0.40 |
| Recovery | 1.42 ± 0.22 | 1.46 ± 0.33 | 1.45 ± 0.24 |
Values are means ± SE. BRS; n, number of rats. spontaneous baroreflex sensitivity. Sequences up (Seq Up), down (Seq Down) and all (Seq All) values were obtained on day 5 of control, day 10 of chronic SHU-9119 infusion (1 nmol/h), and on the last day of the recovery posttreatment period.