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. 2012 Mar 23;7(3):e33853. doi: 10.1371/journal.pone.0033853

Figure 7. Effects of chronic exposure to Cd on CK 8/18 expression in mouse livers.

Figure 7

Expression of hepatic CK8/18 as a new marker of mouse liver preneoplastic change was examined by immunochemical staining (A) and Western blotting (B). In panel A, series of sections of same tissues were conventionally stained with H&E (A-a, c, e, g, i, k) and immunochemically stained with anti-CK8/18 antibodies (A-b, d, f, h, j, l). The results indicated that there was a significant increase in CK8/18 staining foci with little notable change in the same locations using H&E staining. Bar = 50 µm. Data was presented as mean ± SD (n = 10). * p<0.05 vs control; # p<0.05 vs Cd group; & p<0.05 vs 5-aza group.