Table 2. Associations of SERPINF1 SNPs with parameters of body fat content and distribution (overall cohort and MRI/MRS subgroup).
| Genotype | N overall cohort | BMI (kg/m2) | Body fat (%) | Waist circum-ference (cm) | Fasting leptin (ng/mL)* | N MRI/MRS subgroup | Total AT(% BW) | Visceral AT(% BW) | Intrahepatic lipids (%) | |
| rs11658342 | GG | 784 | 29.8±9.0 | 32.1±12.1 | 95±19 | 29.0±33.3 | 144 | 30.2±9.3 | 3.51±1.79 | 6.16±6.75 |
| GA | 909 | 30.4±9.3 | 33.1±11.9 | 96±19 | 29.2±32.9 | 151 | 31.0±9.1 | 3.21±1.70 | 5.81±6.08 | |
| AA | 278 | 30.5±10.3 | 33.0±13.0 | 96±20 | 28.7±35.7 | 44 | 30.0±8.9 | 3.24±1.71 | 5.18±6.69 | |
| padd/pdom | - | - | 0.4/0.3 | 0.6/0.3 | 0.3/0.2 | 0.3/0.4 | - | 0.4/0.5 | 0.7/0.7 | 0.2/0.5 |
| rs1136287 | TT | 788 | 30.5±9.2 | 33.7±12.2 | 96±19 | 30.4±33.8 | 139 | 31.5±8.7 | 3.33±1.77 | 6.03±6.70 |
| TC | 953 | 30.0±9.3 | 32.1±11.9 | 96±19 | 28.0±32.6 | 166 | 30.0±9.3 | 3.34±1.72 | 5.64±6.32 | |
| CC | 233 | 29.9±9.8 | 31.8±12.6 | 95±19 | 29.1±35.3 | 35 | 29.2±10.2 | 3.32±1.82 | 6.45±6.00 | |
| padd/pdom | - | - | 0.3/0.2 | 0.0298/0.06 | 0.2/0.4 | 0.2/0.09 | - | 0.2/0.2 | 0.5/0.4 | 0.6/1.0 |
| rs12603825 | GG | 1,039 | 30.1±9.7 | 32.2±12.4 | 95±19 | 27.8±33.4 | 168 | 29.8±9.6 | 3.22±1.71 | 5.69±6.30 |
| GA | 784 | 30.4±8.9 | 33.4±11.8 | 96±19 | 31.0±34.1 | 138 | 31.3±8.4 | 3.40±1.76 | 5.80±6.17 | |
| AA | 144 | 30.0±8.6 | 32.6±11.8 | 95±17 | 28.2±30.4 | 32 | 31.6±10.0 | 3.60±1.87 | 7.40±8.22 | |
| padd/pdom | - | - | 0.5/0.3 | 0.07/0.0182 | 0.7/0.6 | 0.0155/0.0035 | - | 0.0250/0.0094 | 0.2/0.2 | 0.4/0.4 |
| rs2071021 | AA | 937 | 30.5±9.3 | 33.5±12.3 | 96±19 | 30.6±34.5 | 162 | 31.2±9.2 | 3.30±1.73 | 5.81±6.46 |
| AG | 861 | 29.9±9.3 | 31.9±11.9 | 95±19 | 27.3±32.0 | 150 | 30.0±9.2 | 3.39±1.73 | 6.13±6.78 | |
| GG | 176 | 29.9±9.6 | 32.2±12.3 | 95±19 | 29.6±34.5 | 28 | 29.4±8.7 | 3.29±1.97 | 4.95±3.96 | |
| padd/pdom | - | - | 0.2/0.1 | 0.1/0.1 | 0.2/0.3 | 0.2/0.06 | - | 0.4/0.3 | 0.7/0.8 | 0.6/0.6 |
| rs6828 | CC | 1,005 | 30.1±9.5 | 32.4±12.3 | 96±19 | 27.9±33.4 | 167 | 29.7±9.0 | 3.32±1.78 | 5.79±6.52 |
| CT | 806 | 30.3±9.2 | 32.9±11.9 | 96±20 | 29.9±33.3 | 137 | 31.5±9.0 | 3.26±1.67 | 5.80±5.95 | |
| TT | 161 | 30.5±8.9 | 33.5±12.5 | 95±17 | 31.8±34.1 | 36 | 30.8±10.3 | 3.69±1.86 | 6.62±7.80 | |
| padd/pdom | - | - | 0.4/0.4 | 0.3/0.3 | 0.7/0.7 | 0.05/0.08 | - | 0.1/0.05 | 0.3/0.2 | 0.6/0.5 |
Data are shown as unadjusted raw data (means ±SD). Prior to statistical analysis, all parameters were adjusted for gender and age. padd – p-value, additive inheritance model; pdom – p-value, dominant inheritance model; nominal associations are marked by bold fonts, significant associations by bold fonts and underlining. AT – adipose tissue; BMI – body mass index; BW – body weight; MRI – magnetic resonance imaging; MRS – magnetic resonance spectroscopy; SNP – single nucleotide polymorphism; *available from 1,409 participants.