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. 2012 Mar 23;7(3):e34178. doi: 10.1371/journal.pone.0034178

Table 1. Essential yeast genes that show synthetic sick interactions with Ypk9.

ts allele Yeast Gene Human Homolog Function
alg1-1 ALG1 ALG1 Mannosyltransferase
cdc28-td CDC28 CDK2 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK)
cdc2-1 POL3 POLD1 Catalytic subunit of DNA polymerase delta
cdc53-1 CDC53 CUL1 Cullin, structural protein of SCF complexes
cdc12-td CDC12 SEPT4 Component of the septin ring of the mother-bud neck that is required for cytokinesis
cdc11-4, cdc11-5 CDC11 no Component of the septin ring of the mother-bud neck that is required for cytokinesis
sfh1-1 SFH1 SMARCB1 Component of the RSC chromatin remodeling complex
gab1-1 GAB1 PIGU GPI transamidase subunit
apc5-CA-PAps APC5 no Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase
myo2-16 MYO2 MYO5C One of two type V myosin motors
dim1-2 DIM1 DIMT1L Essential 18S rRNA dimethylase, involved in pre-ribosomal RNA processing
bet2-1 BET2 RABGGTB Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi