Table 4. Cox proportional hazard models for the risk of all-cause deaths according to the use of hormone treatment at baseline.

	Women	Deaths	Follow-up,	Hazard Ratio (95% CI), p
Hormone treatment	N	N	Person-Years	Age-adjusted	Multivariate adjusteda
Never	3576	284	17,568	1 (Referent)	1 (Referent)
Past	845	52	4223	1.04 (0.77–1.41), 0.78	1.04 (0.72–1.41), 0.79
Current	714	16	3645	0.62 (0.37–1.05), 0.07	0.66 (0.39–1.12), 0.12
Characteristics of current users b
≤10 years current use	274	5	1414	0.36 (0.11–1.13), 0.08	0.37 (0.12–1.16), 0.09
>10 years current use	389	10	1970	0.74 (0.42–1.33), 0.31	0.81 (0.45–1.46), 0.49
initiated ≤5 yrs after menopause	385	7	1961	0.57 (0.26–1.22), 0.15	0.62 (0.29–1.34), 0.23
initiated >5 yrs after menopause	275	8	1418	0.75 (0.37–1.54), 0.44	0.77 (0.38–1.58), 0.48
unopposed estradiol HTc	127	5	656	0.95 (0.39–2.32), 0.91	0.94 (0.39–2.30), 0.90
oral estradiol+progestagen HT	121	3	609	0.74 (0.23–2.33), 0.60	0.84 (0.26–2.65), 0.76
transdermal estradiol+progestagen HTd	439	7	2244	0.45 (0.21–0.96), 0.04	0.48 (0.22–1.04), 0.06

^aAdjusted for age, education, recruitment centre, living situation, incapacities, comorbidity, depressive symptoms and cognitive impairment.

^bWith reference to never users.

^c113 (89%) used transdermal estradiol treatment and 14 (11%) oral estradiol.

^dThe 27 women who currently used other types of HT were not included in this analysis;