Table 1. Physiological parameters of mice treated or not with diethylstilbestrol for 7 days.

Urine parameters
	Control	DES 7 days	p values
Volume (ml)	1.3±0.3	2.2±0.3	0.008
Osmolarity (mosm/kgH20)	2654±489	1279±288	0.036
Na+ excretion (mmol/mmol creat)	39.6±3.1	53.2±4.9	0.039
K+ (excretion (mmol/mmol creat)	23.3±1.7	20.8±2.3	0.4
Na+/K+ ratio	1.78±0.07	2.63±0.16	>0.001
Ca2+ (excretion (mmol/mmol creat)	0.4±0.1	0.2±0.05	0.086

Results are shown as mean ± s.e.m. (n = 9). Non-paired Student t-test was used for comparing set of data.