Table 2. The summary of the results in GWAS, replication and combined datasets.
GWA1 | Replication2 | Combined3 | ||||||||||||||
Chromosome | SNP | Position | F_A4 | F_U5 | Praw | PGC | Pgenome | OR | F_A4 | F_U5 | Praw | OR | F_A4 | F_U5 | Praw | OR |
3 | BICF2P397912 | 82766251 | 0.60 | 0.33 | 3.91E-4 | 0.001 | 0.96 | 3.11 | 0.49 | 0.40 | 0.14 | 1.41 | 0.51 | 0.39 | 0.014 | 1.65 |
4 | TIGRP2P58276 | 13088720 | 0.43 | 0.16 | 1.39E-4 | 5.25E-4 | 0.76 | 3.91 | 0.39 | 0.29 | 0.07 | 1.55 | 0.40 | 0.26 | 0.004 | 1.86 |
9 | BICF2P1288768 | 18597315 | 0.43 | 0.47 | 4.71E-4 | 0.001 | 0.98 | 0.31 | 0.43 | 0.47 | 0.53 | 0.86 | 0.38 | 0.47 | 0.078 | 0.69 |
18 | TIGRP2P239410 | 15846321 | 0.15 | 0.47 | 1.68E-5 | 8.95E-5 | 0.18 | 0.21 | 0.30 | 0.39 | 0.10 | 0.67 | 0.27 | 0.43 | 0.001 | 0.49 |
23 | BICF2G630382382 | 22138085 | 0.20 | 0.48 | 1.60E-4 | 5.91E-4 | 0.79 | 0.27 | 0.25 | 0.31 | 0.22 | 0.73 | 0.24 | 0.37 | 0.005 | 0.53 |
37 | BICF2P890779 | 18123961 | 0.53 | 0.18 | 1.34E-6 | 1.09E-5 | 0.02 | 5.41 | 0.72 | 0.50 | 3.72E-05 | 2.59 | 0.76 | 0.49 | 9.70E-10 | 3.29 |
GWAS dataset: 40 cases, 44 controls.
Replication dataset: chromosomes 3, 4, 9, 18, 23: 54 cases, 62 controls; chromosome 37: 81 cases, 88 controls.
Combined dataset: chromosomes 3, 4, 9, 18, 23: 94 cases, 106 controls; chromosome 37: 116 cases, 130 controls.
Frequency of the minor allele (based on GWAS controls) in affected individuals.
Frequency of the minor allele (based on GWAS controls) in unaffected individuals.