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. 2011 Nov 30;107(5):1489–1499. doi: 10.1152/jn.00827.2011

Fig. 6.

Fig. 6.

NO modulation of TASK channels in hypoglossal motoneurons involves cGMP and PKG. A: traces of holding current and conductance show that when HCN channels were blocked with Cs+ (2 mM), exposure to DEA decreased holding current and conductance by ∼25 pA and ∼0.8 nS, respectively. In the continued presence of Cs+, a second exposure to DEA, this time in the presence of 1H-(1,2,4)oxadiazole(4,3-a)quinoxaline-1-one (ODQ; 20 μM), decreased holding current and conductance by only ∼13 pA and ∼0.3 nS, respectively. The asterisks designate a 10-min time break. Right, summary data (n = 13) show that ODQ decreased DEA-sensitivity of the TASK-like conductance. *P < 0.05. B: traces of holding current and conductance show another example where in Cs+, exposure to DEA decreased holding current and conductance by ∼30 pA and ∼2 nS, respectively. A second exposure to DEA in Cs+, this time after ∼4 min of incubation in KT-5823 (1 μM), had negligible effects on holding current or conductance. Right, summary data (n = 4) show that KT-5823 decreased DEA sensitivity of the TASK-like conductance. *P < 0.05.