Table 3.
Biological Effects of 1–8 with and without TRAIL
| compound | EC50a w/TRAILb | EC50a w/o TRAIL | synergistic effectc |
|---|---|---|---|
| 2,3-epoxy-2,3-dihydrolapachol (1) | 16.7 | 39.7 | 2.4 |
| 2,3-epoxy-2,3-dihydro-8-hydroxylapachol (2) | 4.7 | 6.4 | 1.4 |
| 2-methyl-anthraquinone (3) | > 50 | > 50 | NA |
| maritinone (4) | 1.5 | 5.8 | 3.8 |
| elliptinone (5) | 3.8 | 13.2 | 3.5 |
| plumbagin (6) | 3.7 | 7.3 | 2.0 |
| (+)-cis-isoshinanolone (7) | > 60 | > 60 | NA |
| ethylidene-6,6′-biplumbagin (8) | > 30 | > 30 | NA |
a
μM.
b
40 ng/mL.
c
Synergistic effect is defined as the ratio of the two half-maximal (EC50) values obtained from cell death curves.