Table 1.

Summary of EAE development in five independent experiments

Experiment	Mice	Incidence	Mean accumulating score	Mean maximal score	Mean day of onset
1	WT	7/10	22.1 ± 11	1.85 ± 1.42	11.3 ± 0.8
	EBI3−/−	10/10	26.1 ± 7	2.45 ± 0.87	12.43 ± 1.7
2	WT	4/4	22.2 ± 6.1	2.1 ± 0.93	13.75 ± 0.37
	EBI3−/−	5/5	27.7 ± 9.4	3.1 ± 0.88*	13.6 ± 1.36
3	WT	5/5	17.2 + 2.2	1.6 ± 0.32	14.6 ± 0.6
	EBI3−/−	6/6	17 ± 3.3	2 ± 0.5	14.8 ± 0.8
4	WT	6/7	19.6 ± 10.6	2.92 ± 0.9	16.1 ± 4.16
	EBI3−/−	5/5	29.1 ± 4.6	3.6± 0.16*	13 ± 1.2
5	WT	5/5	20.6 ± 7.2	1.4 ± 0.36	13.2 ± 0.32
	EBI3−/−	4/4	29.2 ± 11.8	1.6 ± 0.6	12 ± 0

Mean maximal score=the average of maximal score of each mouse in each experiment. Mean accumulating score=the average of accumulating scores of each mouse. The daily EAE scores of each mouse were added together for a period of 25–40 days to obtain the accumulating score for each mouse. Day of EAE onset was considered as when the first sign of EAE appears in each mouse. Data shown are Mean ± Standard deviations. In experiment#3 and #5, reduced pertussis toxin (100 ng/mouse) was used for the EAE induction.

^*p<0.05 by Mann-Whitney U test.