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. Author manuscript; available in PMC: 2013 Apr 20.
Published in final edited form as: J Mol Biol. 2012 Feb 9;418(1-2):65–81. doi: 10.1016/j.jmb.2012.02.005

Figure 4. Cytidine deamination dinucleotide context analyses of APOBEC-1 hypermutation.

Figure 4

APOBEC-1 hypermutation sequences obtained in Fig. 1E, 2E, and 3 were analyzed according to the 5′ immediate nucleotides of each hypermutated cytidine. The data were summarized and presented in graphs to show their dinucleotide preferences. A, Dinucleotide context analyses of rat and human APOBEC-1 hypermutation on human apoB mRNA by adenoviral expression as in HepG2 cells, Fig. 3. B, Dinucleotide context analyses of rat APOBEC-1 hypermutation on human or rat apoB mRNA by plasmid transfections as in HepG2 cells, Fig. 1E or McA7777 cells, Fig. 2E, respectively.