Fig.1.

Isoflurane slows the decay of γ-aminobutyric acid type A,slow (GABA_A,slow) IPSCs. (A) Whole-cell patch clamp recording of IPSCs in a CA1 pyramidal cell under control conditions, in the presence of 200 µM isoflurane, and after washout (all at 24 °C). The time constant of decay (in ms) and the peak amplitude (in pA) were 85 and 211 (control), 124 and 210 (isoflurane), 82 and 209 (washout). (B) Time series of the experiment illustrating the effect of isoflurane on the decay of GABA_A,slow. Note lack of effect on the amplitude and rapid onset and offset of isoflurane’s effect.