Table 1.
Etomidate modulation of GABAA,slow kinetics does not vary with temperature. Data are presented as mean ± SD.
| [etomidate] (µM) |
T (0C) | n | τcontrol (ms) |
τdrug (ms) |
Ratio (%) (τdrug/τcontrol) |
|---|---|---|---|---|---|
| 0.125 | 34±1 24±1 |
4 5 |
28 ± 10 78 ± 54 |
33 ± 11 97 ± 63 |
119 ± 11% 126 ± 9% |
| 0.25 | 34±1 24±1 |
7 6 |
30 ± 10 82 ± 49 |
55 ± 21 150 ± 72 |
199 ± 52% 196 ± 41% |
| 0.5 | 34±1 24±1 |
4 6 |
22 ± 4 101 ± 48 |
70 ± 27 226 ± 110 |
314 ± 85% 253 ± 49% |
| 1.0 | 34±1 24±1 |
4 3 |
26 ± 7 76 ± 26 |
104 ± 14 283 ± 150 |
441 ± 53% 363 ± 78% |
GABAA,slow- γ-aminobutyric acid type A, slow