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. 2011 Jan 19;31(3):979–991. doi: 10.1523/JNEUROSCI.4960-10.2011

Figure 7.

Figure 7.

GPCR-dependent silencing requires proteasome activity. A, Example action-potential-evoked EPSCs from autaptic neurons treated acutely (<1 min; control) or for 4 h with 10 nm CCPA and 50 μm baclofen with or without 3 μm MG-132. MG-132 was added 30 min before the start of (and remained during) the 4 h treatment. B, Summary of EPSC amplitudes from autaptic neurons treated as in A. *p < 0.05 with Bonferroni's correction for multiple comparisons (n = 15 neurons). C, Example images of vGluT-1 (red) and FM1-43FX (green) correspondence in neurons treated 4 h with or without 10 nm CCPA and 50 μm baclofen in the presence or absence of 3 μm MG-132. MG-132 was added 30 min before the start of the 4 h treatment. Scale bar, 5 μm. D, Summary of experiments measuring vGluT-1/FM1-43FX correspondence in neurons treated as in C. *p < 0.05 with Bonferroni's correction for multiple comparisons (n = 35 fields from 7 independent experiments).