Table 4.
Hazard Ratios of Various Clinic Outcomes in Males Associated for Each Standard Deviation Increase in Individual Tenets of the Metabolic Syndrome Definition
| CVD (N=206) | CHD (N=164) | Stroke (N=40) | Mortality (N=130) | |
|---|---|---|---|---|
| Waist circumference (crude) | 1.29 (1.11–1.51)† | 1.21 (1.02–1.44)* | 1.51 (1.10–2.06)† | 1.06 (0.87–1.29) |
| Model 1 | 1.29 (1.11–1.50)† | 1.21 (1.02–1.45)* | 1.50 (1.09–2.07)* | 0.93 (0.74–1.17) |
| Model 2 | 1.15 (0.97–1.36) | 1.11 (0.91–1.34) | 1.37 (0.95–1.97) | 0.93 (0.73–1.19) |
| Log HOMA (crude model) | 1.33 (1.17–1.52)‡ | 1.32 (1.14–1.52)† | 1.55 (1.16–2.06)† | 1.02 (0.85–1.21) |
| Model 1 | 1.37 (1.20–1.57)‡ | 1.34 (1.15–1.56)‡ | 1.56 (1.16–2.09)† | 1.00 (0.83–1.2) |
| Model 2 | 1.18 (1.00–1.40) | 1.19 (0.99–1.44) | 1.25 (0.87–1.79) | 1.03 (0.82–1.29) |
| Triglycerides (crude model) | 1.09 (1.01–1.18)* | 1.1 (1.01–1.19)* | 1.10 (0.94–1.30) | 0.90 (0.74–1.10) |
| Model 1 | 1.12 (1.05–1.20)† | 1.13 (1.05–1.21)† | 1.14 (0.96–1.34) | 1.01 (0.85–1.21) |
| Model 2 | 1.06 (0.96–1.17) | 1.07 (0.97–1.18) | 1.08 (0.86–1.36) | 1.03 (0.86–1.24) |
| HDL (crude model) | 0.79 (0.65–0.95)* | 0.76 (0.61–0.95)* | 0.82 (0.54–1.26) | 1.10 (0.90–1.36) |
| Model 1 | 0.73 (0.60–0.88)† | 0.71 (0.57–0.89)† | 0.78 (0.51–1.20) | 1.00 (0.81–1.25) |
| Model 2 | 0.81 (0.65–0.99)* | 0.77 (0.61–0.98)* | 0.94 (0.61–1.47) | 1.00 (0.78–1.27) |
| Systolic blood pressure (crude) | 1.65 (1.45–1.88)‡ | 1.46 (1.25–1.70)‡ | 2.44 (1.87–3.18)‡ | 1.37 (1.15–1.63)† |
| Model 1 | 1.49 (1.29–1.71)‡ | 1.31 (1.11–1.55)† | 2.17 (1.63–2.90)‡ | 1.05 (0.87–1.26) |
| Model 2 | 1.45 (1.25–1.68)‡ | 1.29 (1.09–1.53)† | 2.05 (1.52–2.77)‡ | 1.05 (0.87–1.27) |
| Log UAC (crude model) | 1.48 (1.35–1.63)‡ | 1.36 (1.21–1.52)‡ | 1.86 (1.57–2.21)‡ | 1.54 (1.38–1.73)‡ |
| Model 1 | 1.40 (1.26–1.55)‡ | 1.27 (1.12–1.44)† | 1.77 (1.47–2.13)‡ | 1.37 (1.20–1.56)‡ |
| Model 2 | 1.26 (1.12–1.41)‡ | 1.15 (1.00–1.32)* | 1.49 (1.21–1.84)† | 1.37 (1.20–1.56)‡ |
Model 1, race, age, cigarette smoking ( current, ever, never), exercise (>5 METS/h every week), income and education; model 2, model 1+ other metabolic syndrome components (WC, HOMA, HDL, Trig, SBP).
*
P<0.05.
†
P<0.01.
‡
P<0.001.
CVD, all cardiovascular disease events; CHD, all coronary heart disease events; UAC, urine albumin–creatinine ratio; MET, metabolic equivalent; WC, waist circumference; HOMA, homeostasis model assessment; HDL, high-density lipoprotein; Trig, triglycerides; SBP, systolic blood pressure.