Table 5.
Hazard Ratios of Various Clinic Outcomes in Females Associated for Each Standard Deviation Increase in Individual Tenets of the Metabolic Syndrome Definition
| CVD (N=116) | CHD (N=68) | Stroke (N=49) | Mortality (N=94) | |
|---|---|---|---|---|
| Waist circumference (crude) | 1.29 (1.11–1.51)† | 1.30 (1.07–1.58)† | 1.24 (0.98–1.57) | 1.17 (0.99–1.40) |
| Model 1 | 1.25 (1.05–1.49)* | 1.25 (1.00–1.57)* | 1.13 (0.85–1.50) | 1.19 (0.97–1.46) |
| Model 2 | 1.18 (0.98–1.43) | 1.19 (0.93–1.52) | 1.03 (0.76–1.41) | 1.16 (0.94–1.45) |
| Log HOMA (crude model) | 1.28 (1.08–1.53)† | 1.29 (1.02–1.62)* | 1.32 (1.01–1.73)* | 1.18 (0.97–1.44) |
| Model 1 | 1.26 (1.04–1.53)* | 1.28 (1.00–1.65) | 1.33 (1.00–1.79)* | 1.14 (0.92–1.41) |
| Model 2 | 1.11 (0.88–1.40) | 1.14 (0.84–1.55) | 1.26 (0.88–1.81) | 1.06 (0.82–1.37) |
| Triglycerides (crude model) | 1.10 (0.96–1.27) | 1.12 (0.95–1.32) | 1.10 (0.89–1.35) | 0.97 (0.77–1.22) |
| Model 1 | 1.13 (0.94–1.34) | 1.17 (0.96–1.42) | 1.18 (0.88–1.57) | 0.94 (0.72–1.23) |
| Model 2 | 1.07 (0.85–1.35) | 1.15 (0.90–1.46) | 1.08 (0.74–1.58) | 0.84 (0.61–1.17) |
| HDL (crude model) | 0.88 (0.73–1.06) | 0.93 (0.74–1.19) | 0.83 (0.62–1.12) | 0.90 (0.74–1.11) |
| Model 1 | 0.85 (0.69–1.04) | 0.87 (0.67–1.14) | 0.82 (0.60–1.14) | 0.91 (0.73–1.14) |
| Model 2 | 0.92 (0.73–1.16) | 0.99 (0.74–1.32) | 0.89 (0.62–1.27) | 0.90 (0.70–1.17) |
| Systolic blood pressure (crude model) | 1.69 (1.47–1.95)‡ | 1.48 (1.22–1.80)‡ | 1.91 (1.55–2.36)‡ | 1.40 (1.18–1.65) |
| Model 1 | 1.38 (1.17–1.63)‡ | 1.24 (0.99–1.56) | 1.48 (1.15–1.91)† | 1.10 (0.91–1.33) |
| Model 2 | 1.36 (1.15–1.61)† | 1.19 (0.95–1.50) | 1.48 (1.14–1.91)† | 1.10 (0.90–1.33) |
| Log UAC (crude model) | 1.61 (1.41–1.85)‡ | 1.56 (1.30–1.87)‡ | 1.70 (1.40–2.07)‡ | 1.75 (1.52–2.01)‡ |
| Model 1 | 1.44 (1.23–1.69)‡ | 1.42 (1.15–1.74)† | 1.51 (1.20–1.89)† | 1.57 (1.33–1.84)‡ |
| Model 2 | 1.31 (1.11–1.55)† | 1.33 (1.06–1.66)* | 1.33 (1.04–1.71)* | 1.62 (1.36–1.94)‡ |
Model 1, race, age, cigarette smoking (current, ever, never), exercise (>5 METS/h every week), income, and education; model 2, model 1+ other metabolic syndrome components (WC, HOMA, HDL, Trig, SBP).
*
P<0.05.
†
P<0.01.
‡
P<0.001.
CVD, all cardiovascular disease events; CHD, all coronary heart disease events; UAC, urine albumin–creatinine ratio; MET, metabolic equivalent; WC, waist circumference; HOMA, homeostasis model assessment; HDL, high-density lipoprotein; Trig, triglycerides; SBP, systolic blood pressure.