Table 2.
Amphetamine by gene by intensity interaction for N40 amplitude
| Amphetamine (mg/kg) | Stimulus intensity (dB) | Wild type | Transgenic | P-value |
|---|---|---|---|---|
| 0 | 75 | 21±7 | 22±8 | 0.973 |
| 85 | 89±17 | 29±19 | 0.133 | |
| 95 | 181±24 | 54±26 | 0.003 | |
| 0.1 | 75 | 48±12 | 26±13 | 0.568 |
| 85 | 77±18 | 47±19 | 0.436 | |
| 95 | 107±21 | 80±23 | 0.484 | |
| 0.5 | 75 | 21±6 | 15±7 | 0.881 |
| 85 | 47±11 | 12±12 | 0.360 | |
| 95 | 64±13 | 34±14 | 0.440 | |
| 1 | 75 | 13±7 | 17±8 | 0.935 |
| 85 | 15±7 | 12±8 | 0.926 | |
| 95 | 33±10 | 43±11 | 0.800 |
Note that amphetamine dose dependently decreases the normal intensity function (gain) for N40 amplitude in wild type but not transgenic animals. Fisher LSD post hoc analyses (MS=2531, df=77). P-values are listed for wild type vs. transgenic mice.