. Author manuscript; available in PMC: 2012 Mar 25.

Published in final edited form as: Alzheimers Dement. 2011 Apr 21;7(3):263–269. doi: 10.1016/j.jalz.2011.03.005

Table 1.

AD dementia criteria incorporating biomarkers

Diagnostic category	Biomarker probability of AD etiology	Aβ (PET or CSF)	Neuronal injury (CSF tau, FDG-PET, structural MRI)
Probable AD dementia
Based on clinical criteria	Uninformative	Unavailable, conflicting, or indeterminate	Unavailable, conflicting, or indeterminate
With three levels of evidence of AD pathophysiological process	Intermediate Intermediate High	Unavailable or indeterminate Positive Positive	Positive Unavailable or indeterminate Positive
Possible AD dementia (atypical clinical presentation)
Based on clinical criteria	Uninformative	Unavailable, conflicting, or indeterminate	Unavailable, conflicting, or indeterminate
With evidence of AD pathophysiological process	High but does not rule out second etiology	Positive	Positive
Dementia-unlikely due to AD	Lowest	Negative	Negative

Abbreviations: AD, Alzheimer’s disease; Aβ, amyloid-beta; PET, positron emission tomography; CSF, cerebrospinal fluid; FDG, ¹⁸fluorodeoxyglucose; MRI, magnetic resonance imaging.