Table 1.
Cancer risk among people diagnosed with AIDS during childhood relative to the general population
| Cancer type | Pre-HAART era 1980–1995 | HAART era 1996–2007 | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| No. cases | SIR | 95%CI | No. cases | SIR | 95%CI | |
| All cancer | 69 | 40 | (31–51) | 37 | 17 | (12–23) |
| AIDS-defining cancers overall | 58 | 441 | (335–570) | 26 | 130 | (85–190) |
| Kaposi sarcoma | 17 | 1694 | (986–2712) | 3 | 1146 | (236–3349) |
| Non-Hodgkin lymphoma | 41 | 338 | (242–458) | 23 | 116 | (74–175) |
| Diffuse large B-cell lymphoma | 7 | 280 | (112–576) | 14 | 235 | (128–394) |
| Burkitt lymphoma | 10 | 304 | (146–559) | 3 | 84 | (17–246) |
| CNS lymphoma | 5 | 1994 | (647–4656) | 5 | 1088 | (354–2541) |
| Other/unspecified NHL | 24 | 378 | (242–562) | 6 | 59 | (22–127) |
| Cervix | 0 | 0 | (0–8111) | 0 | 0 | (0–916) |
| Non-AIDS-defining cancers overall | 8 | 5 | (2–10) | 11 | 6 | (3–10) |
| Liver | 1 | 47 | (1.2–263) | 0 | 0 | (0–196) |
| Lung | 0 | 0 | (0–1230) | 1 | 108 | (3–602) |
| Soft tissue (other than leiomyosarcoma) | 2 | 21 | (3–77) | 1 | 9 | (0.22–48) |
| Leiomyosarcoma | 4 | 863 | (235–2211) | 5 | 533 | (173–1243) |
| Thyroid | 1 | 90 | (2.3–502) | 0 | 0 | (0–64) |
| Hodgkin lymphoma | 0 | 0 | (0–70) | 1 | 7 | (0.17–38) |
| Lymphocytic leukemia | 0 | 0 | (0–9) | 2 | 5 | (0.64–19) |
| Miscellaneous | 0 | 0 | (0–13) | 1 | 4 | (0.11–25) |
| Poorly specified | 3 | 86 | (18–251) | 0 | 0 | (0–125) |
Bolded values are significant at P<.05. Abbreviations: CI, confidence interval; CNS, central nervous system; NHL, non-Hodgkin lymphoma; SIR, standardized incidence ratio. The overall NHL category includes diffuse large B-cell lymphoma, Burkitt lymphoma, and other/unspecified NHL. The CNS lymphoma category includes any histologic subtype of NHL occurring in the central nervous system and so overlaps with other NHL categories. The poorly specified category includes cancers of any topography with a poorly specified histology (ICD-O histology codes 8000–8005). The all non-AIDS-defining cancers category includes miscellaneous cancers but excludes poorly specified cancers.