Table 2.
Cancer incidence among people diagnosed with AIDS during childhood, by current calendar year period
| Cancer type | Incidence per 100,000 person-years
|
RR | 95%CI | |
|---|---|---|---|---|
| Pre-HAART era 1980–1995 | HAART era 1996–2007 | |||
| All cancer | 559 | 213 | 0.38 | (0.23–0.64) |
| AIDS-defining cancers overall | 470 | 150 | 0.32 | (0.17–0.59) |
| Kaposi sarcoma | 138 | 17 | 0.13 | (0.02–0.74) |
| Non-Hodgkin lymphoma | 332 | 132 | 0.40 | (0.21–0.75) |
| Diffuse large B-cell lymphoma | 57 | 81 | 1.42 | (0.46–4.39) |
| Burkitt lymphoma | 81 | 17 | 0.21 | (0.04–1.04) |
| CNS lymphoma | 41 | 29 | 0.71 | (0.18–2.77) |
| Other/unspecified NHL | 194 | 35 | 0.18 | (0.06–0.49) |
| Non-AIDS-defining cancers overall | 65 | 63 | 0.98 | (0.33–2.86) |
| Soft tissue (other than leiomyosarcoma) | 16 | 6 | 0.35 | (0.01–8.98) |
| Leiomyosarcoma | 32 | 29 | 0.89 | (0.22–3.63) |
Data are for the combined period 1–10 years after AIDS onset. During the pre-HAART era (attained years 1980–1995) there were 12,348 person-years of follow-up, and during the HAART era (attained years 1996–2007) there were 17,394 person-years of follow-up. Rate ratios (RRs) comparing incidence in the two periods were obtained using Poisson regression, Bolded values are significant at P<.05. Abbreviations: CI, confidence interval; CNS, central nervous system; HAART, highly active antiretroviral therapy; NHL, non-Hodgkin lymphoma.