Figure 2.

Relationship among membrane current, intracellular ATP, and extracellular glucose. (A) Peak currents produced by lowering extracellular glucose from 11 to 3 mM depend on intracellular ATP concentration (0.5–5 mM). Current is outward, except at 0.5 mM ATP. (B) Concentration-dependence of glucose-related outward current (with 2 mM intracellular ATP). (C) Outward current produced in low-glucose buffer reversed completely (and became slightly inward) with the A₁R antagonist DPCPX. *p < 0.05, **p < 0.01. Adapted with permission from Kawamura et al. (2010).