Figure 3.

Over time, KDs produce a biphasic effect on locomotor activity based on this compilation of published rodent data. Note that hypoactivity predominated in studies with short diet treatments (≤20 day), whereas hyperactivity predominated with longer treatments (≥30 day). Points were estimated from published graphs and tables in multiple references (Zhao et al., 2004; Murphy et al., 2005; Ziegler et al., 2005; Murphy and Burnham, 2006; Mantis et al., 2009; Oishi et al., 2010; Thio et al., 2010).