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. 2012 Mar 26;3(3):53–60. doi: 10.4331/wjbc.v3.i3.53

Table 1.

Binding parameters for the interaction of IQGAP1(DR6) and CDC42

IQGAP1(DR6) variant ka/l.mol-1.s-1 kd/s-1 KD/μmol/L
Wild type 4900 ± 100 (6.5 ± 0.5) × 10-3 1.3 ± 0.13
S1441E 12 ± 1 (2.7 ± 0.03) × 10-3 220 ± 21
S1443D 5800 ± 100 (4.7 ± 0.2) × 10-3 0.81 ± 0.048
S1441E/S1443D 3600 ± 100 (4.0 ± 0.2) × 10-3 1.1 ± 0.086
M1231I 1800 ± 100 (1.7 ± 0.2) × 10-3 0.90 ± 0.16

These were determined by surface plasmon resonance. The values are reported ± their standard errors as determined by the BIAevaluation fitting programme (see Materials and Methods).