Table 2.
(A) Main Sample: no diabetes | (B) Diabetes Sample | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | P-value | Cases | Controls | P-valuea | |||||
| ||||||||||
No. | % | No. | % | No. | % | No. | % | |||
N | 454 | 454 | 71 | 71 | ||||||
Demographics | ||||||||||
Age (mean, SD) | 53.9 | 7.5 | 53.7 | 9.3 | 0.0006 | 58.5 | 5.0 | 57.9 | 8.3 | 0.5044 |
Gender (n, % male) | 69 | 15% | 69 | 15% | 1.0000 | 13 | 18% | 13 | 18% | 1.0000 |
Employment Status (n, % employed) | 75 | 17% | 75 | 17% | 1.0000 | 3 | 4% | 3 | 4% | 1.0000 |
Months followup (mean) | 11.1 | 2.2 | 11.3 | 1.7 | ||||||
12-month followup | 366 | 81% | 56 | 79% | ||||||
Time to CAPN (mean days, SD) | 147.5 | 82.9 | 137.2 | 85.7 | ||||||
1–3 months | 125 | 27% | 22 | 31% | ||||||
3–6 months | 149 | 33% | 26 | 37% | ||||||
6–9 months | 179 | 39% | 23 | 33% | ||||||
| ||||||||||
Cancer type | ||||||||||
Nonsmall cell lung | 82 | 18% | 82 | 18% | 1.000 | 18 | 25% | 18 | 25% | 1.000 |
Breast | 316 | 70% | 316 | 70% | 1.000 | 42 | 59% | 42 | 59% | 1.000 |
Ovarian | 28 | 6% | 28 | 6% | 1.000 | 7 | 10% | 7 | 10% | 1.000 |
Head and neck | 27 | 6% | 27 | 6% | 1.000 | 4 | 6% | 4 | 6% | 1.000 |
| ||||||||||
Metastatic cancer | 168 | 37% | 164 | 36% | 0.7883 | 33 | 46% | 20 | 28% | 0.0374 |
| ||||||||||
Comorbidities | ||||||||||
Depressive disorders | 23 | 5% | 31 | 7% | 0.2673 | 2 | 3% | 3 | 4% | 0.6547 |
Congestive heart failure | 20 | 4% | 10 | 2% | 0.0412 | 7 | 10% | 8 | 11% | 0.7963 |
Fibromyalgia | 7 | 2% | 7 | 2% | 1.0000 | 4 | 6% | 1 | 1% | 0.1797 |
Obesity | 8 | 2% | 2 | 0% | 0.0578 | 2 | 3% | 0 | 0% | 0.0578 |
Hypertension—uncomplicated | 76 | 17% | 52 | 11% | 0.0164 | 22 | 31% | 24 | 34% | 0.7316 |
Hypertension—complicated | 4 | 1% | 13 | 3% | 0.0290 | 4 | 6% | 0 | 0% | 0.0290 |
Other cancers | 83 | 18% | 74 | 16% | 0.4352 | 17 | 24% | 21 | 30% | 0.4497 |
Charlson Comorbidity Index | 4.4 | 4.3 | 0.4913 | 6.0 | 4.5 | 0.0043 |
CAPN indicates chemotherapy-associated peripheral neuropathy; SD, standard deviation.
a P-values are determined using McNemar tests for proportions and paired t-tests for continuous measures.