Figure 2. In vivo anti-Candida activity of N10K in a systemic model of infection.
A. Effect of N10K treatment (200 µg, i.e. 180 µM, 1, 24, and 48 h postchallenge) on the survival of mice infected intravenously with 7.5×105 cells of C. albicans CA-6. The survival curve of N10K-treated animals was significantly different from that of control mice, treated with an irrelevant peptide (negative control, NC), as assessed by Logrank test (P<0.05). B. Effect of N10K treatment on fungal clearance from kidneys of mice challenged with 5×105 cells of C. albicans CA-6. *, P<0.01 N10K-treated vs mice treated with the negative control peptide (NC).