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. 2009 Aug 20;9(8):6471–6503. doi: 10.3390/s90806471

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© 2009 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 5. — FGF2-antagonist activity of PTX3-derived peptides. A) Schematic representation of the peptides (in grey) spanning the N-terminal domain of PTX3 utilized for the identification of the amino acid sequence 97–110 as the FGF2-binding domain in PTX3 [92]. The synthetic peptides based on the PTX3(97–110) sequence and used for the analysis shown in panel B are reported in black. B) Relationship between the potency of the peptides to inhibit FGF2/FGFR1-IIIc interaction in a SPR assay and HSPG/FGF2/FGFR1 ternary complex formation in a FGF2-dependent CCA assay [expressed as the concentration of peptide required to obtain 50% inhibition (ID₅₀)]. (Data from both the assays were the mean of three independent experiments, performed in duplicate for CCA assay).