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. 2009 Aug 20;9(8):6471–6503. doi: 10.3390/s90806471

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© 2009 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 7. — Correlation between SPR-generated binding parameters for the interaction of FGF2 with K5 derivatives and their antiangiogenic potential. SPR response at equilibrium of K5 derivatives to immobilized FGF2 were plotted versus the capacity of the FGF2 antagonist to inhibit HSPG/FGF2/FGFR1 ternary complex formation in the FGF2-dependent CCA assay (expressed as % of inhibition when the compounds were tested at the dose of 10 μg/mL). The data from CCA assays are the mean value from three different experiments performed in duplicate. The SPR responses at equilibrium are taken from a single experiment out of three giving consistent results.