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. 2012 Feb 28;4(1):10–27.

Table 7.

(De-)Activators and desensitizer of protease-activated-receptor (PAR) 1 to 4 (modified according to [78])

Activators Deactivators
Thrombin (+++); [Trypsin, Granzyme A, Plasmin (-)] Cathepsin G, Elastase, Plasmin, Proteinase 3, Chymotrypsin (Sensitivity, down regulation)
Trypsin (+++), Tryptase, Factor Xa, Proconvertin Cathepsin G, Plasmin, Proteinase 3
Thrombin, Trypsin, Factor X Cathepsin G, Elastase
Thrombin, Trypsin, Cathepsin G ?