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(De-)Activators and desensitizer of protease-activated-receptor (PAR) 1 to 4 (modified according to [78])
| Activators | Deactivators |
|---|---|
| Thrombin (+++); [Trypsin, Granzyme A, Plasmin (-)] | Cathepsin G, Elastase, Plasmin, Proteinase 3, Chymotrypsin (Sensitivity, down regulation) |
| Trypsin (+++), Tryptase, Factor Xa, Proconvertin | Cathepsin G, Plasmin, Proteinase 3 |
| Thrombin, Trypsin, Factor X | Cathepsin G, Elastase |
| Thrombin, Trypsin, Cathepsin G | ? |
