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. Author manuscript; available in PMC: 2012 Mar 26.
Published in final edited form as: Neuroscience. 2010 Apr 13;168(2):543–550. doi: 10.1016/j.neuroscience.2010.04.003

Figure 1. Microinjection of DERM-A594 into the vlPAG produces antinociception and internalization.

Figure 1

Rats were microinjected with vehicle or beta-CNA, followed by DERM-A594 into the vlPAG. A: Microinjection of DERM-A594 produced an increase in hot plate latency compared to baselines and this increase was blocked by pretreating rats with beta-CNA. B: The number of cells labeled with DERM-A594 (red) was assessed using confocal microscopy in the vlPAG at least 100 µm from the microinjection site. C: View of a single vlPAG neuron with DERM-A594 labeling. D: The number of DERM-A594 labeled neurons was decreased in rats pretreated with beta-CNA compared to saline-pretreated animals. E: Labeling for DERM-A594 from a representative animal pretreated with vehicle. F: Labeling for DERM-A594 from a representative animal pretreated with beta-CNA.