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No effect of pre-exposure treatment on morphine potency. Dose response curves for morphine antinociception were the same despite differences in baseline hot plate latencies caused by pre-exposure to the hot plate apparatus. Data were collected on Trial 5 after twice daily exposure to the hot plate (52.5 °C) or a room temperature plate (Normal Plate) for 2 days. Control rats (Home Cage) were handled for 50 s on each trial and then returned to their home cage. N = 8 or 9/group.
