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. 2012 Feb;165(4):829–844. doi: 10.1111/j.1476-5381.2011.01622.x

Figure 2.

Figure 2

The network of LPA and S1P signalling through G protein-coupled receptors. Each LPA and S1P receptor couples to specific classes of G proteins. Ligand-binding activates or inhibits downstream second messenger molecules, and the most prominent cellular effects are illustrated. Rock, Rho-associated kinase; SRF, serum response factor; IP3, inositol 1,4,5-trisphosphate; PLC, phospholipase C; DAG, diacylglycerol; PKC, protein kinase C; MAPK, mitogen-activated protein kinase; PI3K, phosphoinositol 3-kinase; DAG, diacylglycerol.