Figure 9.

Assessment of anxiety-like behaviors of DBA/2 mice in the LDB paradigm. Panels A–B: assessment of DBA/2 mice response to anxiety-like stimuli in the LDB test. The time spent in the light box was recorded for 5 min. Panels C–D: chronic dose-response effects of AM630 in DBA/2 mice in the LDB test. Mice were injected with AM630 (1, 2 or 3 mg·kg⁻¹, i.p., twice a day) or its saline vehicle for 7 days. On day 8, treated mice were exposed to LDB test for 5 min. Columns represent the mean and vertical lines represent the SEM of the different parameters. * DBA/2 mice significantly different from Swiss ICR mice. ^#P < 0.05, significantly different from vehicle group.