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Effects of a selective ETA receptor antagonist ambrisentan on SBP, UAE, and CCr. (A) Ambrisentan significantly decreases SBP of WT sFlt-1 and eNOS−/− sFlt-1 mice. (B) Ambrisentan decreases daily UAE more in eNOS−/− sFlt-1 mice than in WT sFlt-1 mice. (C) Ambrisentan increases CCr in eNOS−/− sFlt-1 mice. n≥5 for each group.
