Figure 7.

Ambrisentan prevents loss of endothelial fenestration and effacement of podocyte foot processes. (A–D) Representative electron micrographs of glomeruli from WT sFlt-1 and eNOS^−/− sFlt-1 mice with and without ambrisentan treatment. Arrow: the loss of endothelial fenestration; broken arrows: effacement of foot process. Insets: higher magnification of demarcated boxes showing podocytes, endothelial cells and GBM. (E) FPW. (F) Number of slits in 1-mm GBM. Data were obtained from electron micrographs and calculated as described in the Concise Methods. n≥5 for each group. Bars, 2 μm.