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. 2012 Apr;18(4):605–609. doi: 10.1261/rna.032011.111

FIGURE 1.

FIGURE 1.

Model of RF3 function on the ribosome, with boxed step indicating the structure defined in Zhou et al. (2011) and Jin et al. (2011). Steps are outlined as follows: (1) binding of class I release factor (RF1/2) to stop codon programmed ribosomes and catalysis of peptide release; (2) RF3 binding to the ribosome—it is unclear at this stage whether RF3 binds in its GTP- or GDP-bound state; additionally, the ribosome may be in a nonratcheted or ratcheted state (rotation lightly indicated); (3) RF1/2 dissociating from the ribosome; (4) RF3:GDPNP:ribosome complex characterized in Zhou et al. (2011) and Jin et al. (2011); ratcheted state of ribosome is indicated; (5) departure of RF3:GDP from the ribosome following GTP hydrolysis.