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. 2012 Apr;18(4):825–843. doi: 10.1261/rna.029520.111

FIGURE 1.

FIGURE 1.

The genomic architecture of the lncRNAs. The lengths are shown in nucleotides. When the difference between the two groups is statistically significant, the P-values obtained using the Kolmogorov-Smirnov test (KS test; see Materials and Methods) are indicated on top. For details on the box plots, see Materials and Methods. (mRNA) Protein-coding RNAs. (A) The lncRNA genes are significantly shorter than the protein-coding genes. (B,C) The lncRNAs contain fewer introns compared with protein-coding RNAs. (D) The mature, spliced transcripts of lncRNAs and protein-coding RNAs are not significantly different in size. (E) Introns in lncRNAs are similar in size to those in protein-coding RNAs. (F) Distribution of the GC content of individual RNAs in the functionally validated lncRNAs (series labeled lncRNAs), mRNAs, and lncRNAs obtained in a large-scale analysis (Guttman et al. 2009; Khalil et al. 2009). (G) In lncRNAs that contain introns, the exons are longer than those in protein-coding RNAs. (H) The length of intron-less RNAs in both lncRNAs and protein-coding RNAs.