Table 2.
Serum levels of cytokines and oxidative stress markers in study participants according to age group
| Group 1 | Group 2 | Group 3 | Group 4 | Difference by group P < 0.05 | P for interaction | |
|---|---|---|---|---|---|---|
| 22–31 years (n = 30) | 32–41 years (n = 48) | 42–51 years (n = 63) | 52–63 years (n = 67) | |||
| Age (years) | 26.7 ± 0.54 | 37.4 ± 0.40 | 47.8 ± 0.35 | 54.5 ± 0.34 | – | – |
| Postmenopause (%) | 0 | 0 | 49.2 | 94.0 | 1, 2 vs. 3, 4;3 vs. 4 | – |
| Serum IL-6 (pg/mL)a | 2.31 ± 0.30 | 2.75 ± 0.23 | 3.87 ± 0.57 | 5.10 ± 0.79 | 1, 2 vs. 4 | 0.024 |
| Serum TNF-α (pg/mL)a | 8.04 ± 1.39 | 6.86 ± 1.17 | 7.67 ± 1.77 | 6.90 ± 0.91 | NS | 0.422 |
| Serum IL-1ß (pg/mL)a | 0.79 ± 0.20 | 0.58 ± 0.05 | 0.89 ± 0.27 | 0.78 ± 0.20 | NS | 0.443 |
| Plasma ox-LDL(μ/L)a | 36.4 ± 1.93 | 43.2 ± 2.23 | 48.4 ± 2.30 | 59.9 ± 2.70 | 1 vs. 3, 4; 2, 3 vs. 4 | 0.065 |
| Urinary 8-epi-PGF2a (pg/mg creatinine)a | 1,072.9 ± 57.0 | 1,167.1 ± 52.2 | 1,110.9 ± 52.9 | 1,301.8 ± 58.2 | 3 vs. 4 | 0.937 |
Data are mean ± SE or percentage
aTested by log-transformed. Tested by one-way ANOVA with Bonferroni method
P for interaction: p values for the interaction terms between age and menopause were obtained in the multivariate interaction test in a regression model